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One of these classes (class I ferroptosis-inducing compounds, erastin derivatives) inhibits GPX4 through the depletion of glutathione, and the other (class II ferroptosis-inducing compounds, RSL3 derivatives) inhibits GPX4 directly, without glutathione depletion

Similarly, we cannot assess what participation levels clinicians or practices who may use these APCM codes have reported MIPS in the past (for example, eligibility requirements and special statuses, participation at the individual, group, virtual group, or APM Entity level, or reporting via traditional MIPS, the APP, or MVPs), or if they will be MIPS eligible clinicians in future years

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